ASIC1 antibody (AA 195-297)
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- Target See all ASIC1 (ACCN2) Antibodies
- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
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Binding Specificity
- AA 195-297
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ASIC1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Acid-sensing ion channel 1 protein (195-297AA)
- Isotype
- IgG
- Top Product
- Discover our top product ACCN2 Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
- Alternative Name
- ASIC1 (ACCN2 Products)
- Synonyms
- ACCN2 antibody, ASIC antibody, BNaC2 antibody, Accn2 antibody, ASIC1 antibody, AI843610 antibody, ASIC1a antibody, B530003N02Rik antibody, acid sensing ion channel subunit 1 antibody, acid-sensing (proton-gated) ion channel 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody, ASIC1 antibody, Asic1 antibody, asic1 antibody, SMARCD1 antibody
- Background
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Background: Isoform 2 and isoform 3 function as proton-gated sodium channels, they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Aliases: ACCN2 antibody, ACCN2_HUMAN antibody, Acid sensing ion channel 1 antibody, Acid sensing ion channel 1a protein antibody, Acid sensing ion channel antibody, Acid-sensing ion channel 1 antibody, AI843610 antibody, Amiloride sensitive cation channel 2 neuronal antibody, Amiloride-sensitive cation channel 2 antibody, ASIC antibody, ASIC1 antibody, ASIC1A antibody, B530003N02Rik antibody, BNaC2 antibody, Brain sodium channel 2 antibody, Cation channel amiloride sensitive neuronal 2 antibody, hBNaC2 antibody, neuronal antibody
- UniProt
- P78348
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