ARPC2 antibody (AA 1-250)

Catalog No. ABIN7143085

This anti-ARPC2 antibody is a Rabbit Polyclonal antibody detecting ARPC2 in ELISA and IHC. Suitable for Human.

Quick Overview for ARPC2 antibody (AA 1-250) (ABIN7143085)

Target: ARPC2 (Actin Related Protein 2/3 Complex, Subunit 2, 34kDa (ARPC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARPC2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-ARPC2 Antibody

Binding Specificity: AA 1-250

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Actin-related protein 2/3 complex subunit 2 protein (1-250AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARPC2

Target: ARPC2 (Actin Related Protein 2/3 Complex, Subunit 2, 34kDa (ARPC2))

Alternative Name: ARPC2

Background:

Background: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Aliases: Actin related protein 2/3 complex subunit 2 34 kDa antibody, Actin related protein 2/3 complex subunit 2 antibody, Actin-related protein 2/3 complex subunit 2 antibody, ARC 34 antibody, ARC34 antibody, Arp2/3 complex 34 kDa subunit antibody, ARP2/3 protein compex subunit 34 antibody, ARPC 2 antibody, Arpc2 antibody, ARPC2_HUMAN antibody, p34 Arc antibody, p34-ARC antibody, p34Arc antibody, PNAS 139 antibody, PNAS139 antibody, PRO 2446 antibody, PRO2446 antibody

UniProt: O15144

Pathways: RTK Signaling, Regulation of Actin Filament Polymerization