NUDT5 antibody (AA 34-166) (Biotin)

Catalog No. ABIN7143531

The Rabbit Polyclonal anti-NUDT5 antibody is suitable to detect NUDT5 in samples from Human. It has been validated for ELISA.

Quick Overview for NUDT5 antibody (AA 34-166) (Biotin) (ABIN7143531)

Target: NUDT5 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 5 (NUDT5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUDT5 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-NUDT5 Antibody (Biotin)

Binding Specificity: AA 34-166

Purpose: NUDT5 Antibody, Biotin conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human ADP-sugar pyrophosphatase protein (34-166AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NUDT5

Target: NUDT5 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 5 (NUDT5))

Alternative Name: NUDT5

Background:

Background: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity).

Aliases: ADP sugar pyrophosphatase antibody, ADP-sugar pyrophosphatase antibody, hYSAH 1 antibody, hYSAH1 antibody, Nucleoside diphosphate linked moiety X motif 5 antibody, Nucleoside diphosphate linked moiety X type motif 5 antibody, Nucleoside diphosphate-linked moiety X motif 5 antibody, Nudix (nucleoside diphosphate linked moiety X) type motif 5 antibody, Nudix motif 5 antibody, Nudix type motif 5 antibody, NUDT 5 antibody, Nudt5 antibody, NUDT5_HUMAN antibody, YSA1 antibody, YSA1H antibody

UniProt: Q9UKK9