AKR1C4 antibody (AA 1-323)

Catalog No. ABIN7143696

The Rabbit Polyclonal anti-AKR1C4 antibody has been validated for WB, ELISA and IHC. It is suitable to detect AKR1C4 in samples from Human.

Quick Overview for AKR1C4 antibody (AA 1-323) (ABIN7143696)

Target: AKR1C4 (Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1C4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-AKR1C4 Antibody

Binding Specificity: AA 1-323

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Aldo-keto reductase family 1 member C4 protein (1-323AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AKR1C4

Target: AKR1C4 (Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

Alternative Name: AKR1C4

Background:

Background: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Aliases: 3 alpha HSD1 antibody, 3-alpha-HSD1 antibody, 3-alpha-hydroxysteroid dehydrogenase type I antibody, AK1C4_HUMAN antibody, AKR1C4 antibody, Aldo keto reductase family 1 member C4 antibody, Aldo-keto reductase family 1 member C4 antibody, CDR antibody, Chlordecone reductase antibody, DD-4 antibody, DD4 antibody, Dihydrodiol dehydrogenase 4 antibody, HAKRA antibody, HSD3a antibody

UniProt: P17516

Pathways: Steroid Hormone Biosynthesis