ALOX12B antibody (AA 484-663)

Catalog No. ABIN7144524

The Rabbit Polyclonal anti-ALOX12B antibody is suitable to detect ALOX12B in samples from Human. It has been validated for IHC and ELISA.

Quick Overview for ALOX12B antibody (AA 484-663) (ABIN7144524)

Target: ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALOX12B antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-ALOX12B Antibody

Binding Specificity: AA 484-663

Purpose: ALOX12B Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ALOX12B

Target: ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))

Alternative Name: ALOX12B

Background:

Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.

Aliases: ALOX12B antibody, Arachidonate 12-lipoxygenase antibody, 12R-type antibody, 12R-LOX antibody, 12R-lipoxygenase antibody, EC 1.13.11.- antibody, Epidermis-type lipoxygenase 12 antibody

UniProt: O75342

Pathways: Cell-Cell Junction Organization