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ALOX12B antibody (AA 484-663) (HRP)

ALOX12B Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7144527
  • Target See all ALOX12B Antibodies
    ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))
    Binding Specificity
    • 8
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 484-663
    Reactivity
    • 22
    • 1
    Human
    Host
    • 21
    • 2
    Rabbit
    Clonality
    • 22
    • 1
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 2
    • 2
    • 2
    This ALOX12B antibody is conjugated to HRP
    Application
    • 19
    • 16
    • 16
    • 13
    • 3
    • 2
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA)
    Isotype
    IgG
    Top Product
    Discover our top product ALOX12B Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))
    Alternative Name
    ALOX12B (ALOX12B Products)
    Synonyms
    ALOX12B antibody, MGC107915 antibody, MGC85124 antibody, 12R-LOX antibody, ARCI2 antibody, Aloxe2 antibody, e-LOX2 antibody, arachidonate 12-lipoxygenase, 12R type antibody, arachidonate 12-lipoxygenase, 12R type S homeolog antibody, ALOX12B antibody, alox12b antibody, alox12b.S antibody, Alox12b antibody
    Background

    Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.

    Aliases: ALOX12B antibody, Arachidonate 12-lipoxygenase antibody, 12R-type antibody, 12R-LOX antibody, 12R-lipoxygenase antibody, EC 1.13.11.- antibody, Epidermis-type lipoxygenase 12 antibody

    UniProt
    O75342
    Pathways
    Cell-Cell Junction Organization
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