DDX11 antibody (AA 1-220)

Catalog No. ABIN7144962

Product Details anti-DDX11 Antibody

Target: DDX11 (DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (DDX11))

Binding Specificity: AA 1-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDX11 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human ATP-dependent DNA helicase DDX11 protein (1-220AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DDX11

Target: DDX11 (DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (DDX11))

Alternative Name: DDX11 (DDX11 Products)

Synonyms: CHL1 antibody, CHLR1 antibody, KRG2 antibody, WABS antibody, 4732462I11Rik antibody, essa15a antibody, putative ATP-dependent RNA helicase DDX11-like protein 8 antibody, DEAD/H-box helicase 11 antibody, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 antibody, LOC100448472 antibody, DDX11 antibody, Ddx11 antibody

Background:

Background: DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5\\\' to 3\\\' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5\\\'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA.

Aliases: CHL1 antibody, CHL1 related helicase gene 1 antibody, CHL1-like helicase homolog antibody, CHL1-related protein 1 antibody, CHLR1 antibody, Ddx11 antibody, DDX11_HUMAN antibody, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 antibody, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 antibody, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) antibody, DEAD/H box antibody, DEAD/H box protein 11 antibody, hCHLR1 antibody, Keratinocyte growth factor regulated gene 2 protein antibody, Keratinocyte growth factor-regulated gene 2 protein antibody, KRG 2 antibody, KRG-2 antibody, KRG2 antibody, MGC133249 antibody, MGC9335 antibody, OTTHUMP00000238778 antibody, OTTHUMP00000238780 antibody, OTTHUMP00000238784 antibody, OTTHUMP00000238785 antibody, Probable ATP dependent RNA helicase DDX11 antibody, Probable ATP-dependent RNA helicase DDX11 antibody, WABS antibody

UniProt: Q96FC9

Pathways: ER-Nucleus Signaling