ATG5 antibody (AA 5-272) (Biotin)

Catalog No. ABIN7145092

This anti-ATG5 antibody is a Rabbit Polyclonal antibody detecting ATG5 in ELISA. Suitable for Human.

Quick Overview for ATG5 antibody (AA 5-272) (Biotin) (ABIN7145092)

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG5 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-ATG5 Antibody (Biotin)

Binding Specificity: AA 5-272

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Autophagy protein 5 protein (5-272AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ATG5

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Alternative Name: ATG5

Background:

Background: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.

Aliases: APG 5 antibody, APG 5L antibody, APG5 antibody, APG5 autophagy 5 like antibody, APG5 like antibody, APG5-like antibody, APG5L antibody, Apoptosis specific protein antibody, Apoptosis-specific protein antibody, ASP antibody, ATG 5 antibody, Atg5 antibody, ATG5 autophagy related 5 homolog antibody, ATG5_HUMAN antibody, Autophagy protein 5 antibody, Autophagy related 5 antibody, hAPG5 antibody, Homolog of S Cerevisiae autophagy 5 antibody, OTTHUMP00000040507 antibody

UniProt: Q9H1Y0

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy