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BBS5 antibody (AA 224-317) (HRP)

BBS5 Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7145245
  • Target See all BBS5 Antibodies
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    Binding Specificity
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 224-317
    Reactivity
    • 14
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 11
    • 3
    Rabbit
    Clonality
    • 13
    • 1
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    This BBS5 antibody is conjugated to HRP
    Application
    • 11
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Bardet-Biedl syndrome 5 protein (224-317AA)
    Isotype
    IgG
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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    Alternative Name
    BBS5 (BBS5 Products)
    Synonyms
    zgc:56578 antibody, 1700049I01Rik antibody, 2700023J09Rik antibody, Bardet-Biedl syndrome 5 antibody, Bardet-Biedl syndrome 5 (human) antibody, bbs5 antibody, BBS5 antibody, Bbs5 antibody
    Background

    Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

    Aliases: Bardet Biedl syndrome 5 protein antibody, Bardet-Biedl syndrome 5 protein antibody, BBS5 antibody, BBS5_HUMAN antibody

    UniProt
    Q8N3I7
    Pathways
    Hedgehog Signaling
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