JMJD6 antibody (AA 1-320)

Catalog No. ABIN7145557

Product Details anti-JMJD6 Antibody

Target: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Binding Specificity: AA 1-320

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMJD6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 protein (1-320AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for JMJD6

Target: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Alternative Name: JMJD6 (JMJD6 Products)

Synonyms: Ptdsr antibody, PSR antibody, PTDSR antibody, PTDSR1 antibody, psr antibody, ptdsr antibody, zfpsr antibody, zgc:66264 antibody, 5730436I23Rik antibody, D11Ertd195e antibody, PtdSerR antibody, mKIAA0585 antibody, GB15204 antibody, jmjd6 antibody, cg5383 antibody, ptdsr1 antibody, arginine demethylase and lysine hydroxylase antibody, jumonji domain containing 6 antibody, bifunctional arginine demethylase and lysyl-hydroxylase PSR antibody, jmjC domain-containing protein 4 homolog antibody, phosphatidylserine receptor antibody, jumonji domain containing 6 S homeolog antibody, jumonji domain containing 6 L homeolog antibody, Jmjd6 antibody, JMJD6 antibody, jmjd6 antibody, LOC411069 antibody, LOC5577546 antibody, CpipJ_CPIJ004848 antibody, CpipJ_CPIJ019866 antibody, jmjd6.S antibody, jmjd6.L antibody

Background:

Background: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at \\\'Arg-2\\\' (H3R2me) and histone H4 at \\\'Arg-3\\\' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

Aliases: Apoptotic cell clearance receptor antibody, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody, Histone arginine demethylase JMJD6 antibody, JmjC domain-containing protein 6 antibody, JMJD 6 antibody, JMJD6 antibody, JMJD6_HUMAN antibody, Jumonji domain containing 6 antibody, Jumonji domain-containing protein 6 antibody, KIAA0585 antibody, Lysyl-hydroxylase JMJD6 antibody, Peptide-lysine 5-dioxygenase JMJD6 antibody, Phosphatidylserine receptor antibody, Protein PTDSR antibody, PSR antibody, PTDSR 1 antibody, PTDSR antibody, PTDSR1 antibody

UniProt: Q6NYC1