BAZ2A antibody (AA 97-266)

Catalog No. ABIN7145796

Product Details anti-BAZ2A Antibody

Target: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Binding Specificity: AA 97-266

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAZ2A antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Bromodomain adjacent to zinc finger domain protein 2A protein (97-266AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BAZ2A

Target: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Alternative Name: BAZ2A (BAZ2A Products)

Synonyms: zgc:101601 antibody, tip5 antibody, bax2a antibody, walp3 antibody, TIP5 antibody, WALp3 antibody, AA415431 antibody, C030005G16Rik antibody, C78388 antibody, Tip5 antibody, Walp3 antibody, mKIAA0314 antibody, bromodomain adjacent to zinc finger domain, 2A antibody, bromodomain adjacent to zinc finger domain 2A antibody, bromodomain adjacent to zinc finger domain 2A L homeolog antibody, Baz2a antibody, baz2a antibody, BAZ2A antibody, baz2a.L antibody

Background:

Background: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on \\\'Lys-16\\\' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

Aliases: BAZ2A antibody, KIAA0314 antibody, TIP5Bromodomain adjacent to zinc finger domain protein 2A antibody, Transcription termination factor I-interacting protein 5 antibody, TTF-I-interacting protein 5 antibody, Tip5 antibody, hWALp3 antibody

UniProt: Q9UIF9