BRD7 antibody (AA 601-651) (Biotin)

Catalog No. ABIN7145817

The Rabbit Polyclonal anti-BRD7 antibody has been validated for ELISA. It is suitable to detect BRD7 in samples from Human.

Quick Overview for BRD7 antibody (AA 601-651) (Biotin) (ABIN7145817)

Target: BRD7 (Bromodomain Containing 7 (BRD7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRD7 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-BRD7 Antibody (Biotin)

Binding Specificity: AA 601-651

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Bromodomain-containing protein 7 protein (601-651AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BRD7

Target: BRD7 (Bromodomain Containing 7 (BRD7))

Alternative Name: BRD7

Background:

Background: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at \\\'Tyr-216\\\'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at \\\'Lys-9\\\' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at \\\'Lys-382\\\', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Aliases: 75 kDa bromodomain protein antibody, BP75 antibody, BRD 7 antibody, BRD7 antibody, BRD7_HUMAN antibody, Bromodomain containing 7 antibody, bromodomain containing protein 7 antibody, Bromodomain-containing protein 7 antibody, CELTIX 1 antibody, CELTIX1 antibody, NAG4 antibody, Protein CELTIX-1 antibody

UniProt: Q9NPI1