CAMK1 antibody (AA 166-265) (Biotin)

Catalog No. ABIN7146429

The Rabbit Polyclonal anti-CAMK1 antibody has been validated for ELISA. It is suitable to detect CAMK1 in samples from Human.

Quick Overview for CAMK1 antibody (AA 166-265) (Biotin) (ABIN7146429)

Target: CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMK1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CAMK1 Antibody (Biotin)

Binding Specificity: AA 166-265

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Calcium/calmodulin-dependent protein kinase type 1 protein (166-265AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CAMK1

Target: CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))

Alternative Name: CAMK1

Background:

Background: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on \'Ser-694\', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on \'Ser-91\', \'Ser-92\', \'Ser-93\' and \'Ser-294\'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of \'Ser-259\' and \'Ser-498\' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on \'Ser-276\' and \'Ser-295\'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Aliases: Calcium / calmodulin dependent protein kinase 1 antibody, Calcium / calmodulin dependent protein kinase I antibody, Calcium / calmodulin dependent protein kinase type 1 antibody, Calcium/calmodulin dependent protein kinase 1 antibody, Calcium/calmodulin dependent protein kinase I antibody, Calcium/calmodulin dependent protein kinase type 1 antibody, Calcium/calmodulin-dependent protein kinase type 1 antibody, CaM K1 antibody, CaM KI antibody, CaM kinase 1 alpha antibody, CAM kinase 1 antibody, CaM kinase I alpha antibody, CaM kinase I antibody, CaM-KI antibody, CaMK 1 antibody, CAMK I antibody, CaMK1 alpha antibody, CAMK1 antibody, CAMK1 PEN antibody, CaMKI alpha antibody, CaMKI-alpha antibody, KCC1A_HUMAN antibody, MGC120317 antibody, MGC120318 antibody

UniProt: Q14012

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Smooth Muscle Cell Migration