CHST14 antibody (AA 70-133)

Catalog No. ABIN7146684

The Rabbit Polyclonal anti-CHST14 antibody has been validated for WB, ELISA and IHC. It is suitable to detect CHST14 in samples from Human.

Quick Overview for CHST14 antibody (AA 70-133) (ABIN7146684)

Target: CHST14 (Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 14 (CHST14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHST14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CHST14 Antibody

Binding Specificity: AA 70-133

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Carbohydrate sulfotransferase 14 protein (70-133AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHST14

Target: CHST14 (Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 14 (CHST14))

Alternative Name: CHST14

Background:

Background: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.

Aliases: 2600016L03Rik antibody, ATCS antibody, Carbohydrate (N acetylgalactosamine 4 0) sulfotransferase 14 antibody, Carbohydrate sulfotransferase 14 antibody, CHST14 antibody, CHSTE_HUMAN antibody, D4ST-1 antibody, D4st1 antibody, Dermatan 4-sulfotransferase 1 antibody, hD4ST1 antibody, RP23-286G12.2 antibody, UNQ1925/PRO4400 antibody

UniProt: Q8NCH0

Pathways: Glycosaminoglycan Metabolic Process