CBR1 antibody (AA 176-268)

Catalog No. ABIN7146741

The Rabbit Polyclonal anti-CBR1 antibody has been validated for WB, ELISA and IF. It is suitable to detect CBR1 in samples from Human.

Quick Overview for CBR1 antibody (AA 176-268) (ABIN7146741)

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-CBR1 Antibody

Binding Specificity: AA 176-268

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Carbonyl reductase [NADPH] 1 protein (176-268AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CBR1

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Alternative Name: CBR1

Background:

Background: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Aliases: 15 hydroxyprostaglandin dehydrogenase [NADP+] antibody, 15-hydroxyprostaglandin dehydrogenase [NADP+] antibody, Carbonyl reductase [NADPH] 1 antibody, Carbonyl Reductase 1 antibody, CBR 1 antibody, CBR1 antibody, CBR1_HUMAN antibody, CRN antibody, NADPH dependent carbonyl reductase 1 antibody, NADPH-dependent carbonyl reductase 1 antibody, Prostaglandin 9 ketoreductase antibody, Prostaglandin 9-ketoreductase antibody, Prostaglandin E(2) 9 reductase antibody, Prostaglandin-E(2) 9-reductase antibody, SDR21C1 antibody

UniProt: P16152