Phospholamban antibody (AA 1-52) (Biotin)

Catalog No. ABIN7146813

The Rabbit Polyclonal anti-Phospholamban antibody has been validated for ELISA. It is suitable to detect Phospholamban in samples from Human.

Quick Overview for Phospholamban antibody (AA 1-52) (Biotin) (ABIN7146813)

Target: Phospholamban (PLN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholamban antibody is conjugated to Biotin

Application: ELISA

Product Details anti-Phospholamban Antibody (Biotin)

Binding Specificity: AA 1-52

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cardiac phospholamban protein (1-52AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Phospholamban

Target: Phospholamban (PLN)

Alternative Name: PLN

Background:

Background: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Aliases: Cardiac phospholamban antibody, CMD1P antibody, CMH18 antibody, PLB antibody, Pln antibody, PPLA_HUMAN antibody

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity