CNOT1 antibody (AA 604-867)

Catalog No. ABIN7147089

The Rabbit Polyclonal anti-CNOT1 antibody has been validated for ELISA, IHC and IF. It is suitable to detect CNOT1 in samples from Human.

Quick Overview for CNOT1 antibody (AA 604-867) (ABIN7147089)

Target: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CNOT1 Antibody

Binding Specificity: AA 604-867

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human CCR4-NOT transcription complex subunit 1 protein (604-867AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CNOT1

Target: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Alternative Name: CNOT1

Background:

Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3\'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

Aliases: CNOT1 antibody, CDC39 antibody, KIAA1007 antibody, NOT1 antibody, AD-005CCR4-NOT transcription complex subunit 1 antibody, CCR4-associated factor 1 antibody, Negative regulator of transcription subunit 1 homolog antibody, NOT1H antibody, hNOT1 antibody

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance