RAD1 antibody (AA 1-282)

Catalog No. ABIN7147263

Product Details anti-RAD1 Antibody

Target: RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))

Binding Specificity: AA 1-282

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Cell cycle checkpoint protein RAD1 protein (1-282AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RAD1

Target: RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))

Alternative Name: RAD1 (RAD1 Products)

Synonyms: HRAD1 antibody, REC1 antibody, zgc:56502 antibody, zgc:77779 antibody, RAD1 antibody, xrad1 antibody, DKFZp459H1127 antibody, RAD1 checkpoint DNA exonuclease antibody, RAD1 homolog (S. pombe) antibody, RAD1 antibody, Rad1 antibody, rad1 antibody

Background:

Background: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\\\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3\\\'->5\\\' double stranded DNA exonuclease activity.

Aliases: Cell cycle checkpoint protein Hrad1 antibody, Cell cycle checkpoint protein Rad 1 A / B antibody, Cell cycle checkpoint protein RAD1 antibody, Checkpoint control protein HRAD1 antibody, Checkpoint control protein RAD1 antibody, DNA repair exonuclease antibody, DNA repair exonuclease rad1 antibody, DNA repair exonuclease rad1 homolog antibody, DNA repair exonuclease REC1 antibody, DNA repair protein RAD1 antibody, EC 3.1.11.2 antibody, Exonuclease homolog RAD1 antibody, GTP-binding protein RAD antibody, hRAD 1 antibody, hRAD1 antibody, MGC77779 antibody, RAD 1 antibody, RAD antibody, RAD1 antibody, RAD1 homolog (S. pombe) antibody, RAD1 homolog antibody, Rad1 like DNA damage checkpoint antibody, Rad1 like DNA damage checkpoint protein antibody, RAD1, S. pombe, homolog of antibody, Rad1-like DNA damage checkpoint protein antibody, RAD1_HUMAN antibody, Ras associated with diabetes antibody, REC 1 antibody, REC1 antibody, RRAD antibody

UniProt: O60671

Pathways: M Phase