CMKLR1 antibody (AA 321-373)

Catalog No. ABIN7147549

This anti-CMKLR1 antibody is a Rabbit Polyclonal antibody detecting CMKLR1 in ELISA, IHC and IF. Suitable for Human.

Quick Overview for CMKLR1 antibody (AA 321-373) (ABIN7147549)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMKLR1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CMKLR1 Antibody

Binding Specificity: AA 321-373

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Chemokine-like receptor 1 protein (321-373AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Alternative Name: CMKLR1

Background:

Background: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Aliases: CHEMERINR antibody, Chemokine like receptor 1 antibody, Chemokine-like receptor 1 antibody, CHEMR23 antibody, CMKLR1 antibody, CML1_HUMAN antibody, DEZ antibody, G protein coupled receptor ChemR23 antibody, G protein coupled receptor DEZ antibody, G-protein coupled receptor ChemR23 antibody, G-protein coupled receptor DEZ antibody, Orphan G protein coupled receptor antibody, Orphan G protein coupled receptor Dez antibody, Resolvin E1 receptor antibody, RVER1 antibody

UniProt: Q99788