NG2 antibody (AA 1950-2210)

Catalog No. ABIN7147644

Product Details anti-NG2 Antibody

Target: NG2 (MCSP) (Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP))

Binding Specificity: AA 1950-2210

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NG2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Chondroitin sulfate proteoglycan 4 protein (1950-2210AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NG2

Target: NG2 (MCSP) (Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP))

Alternative Name: CSPG4 (MCSP Products)

Synonyms: HMW-MAA antibody, MCSP antibody, MCSPG antibody, MEL-CSPG antibody, MSK16 antibody, NG2 antibody, 4732461B14Rik antibody, AN2 antibody, Ng2 antibody, HSMCSGEN1 antibody, MCS antibody, chondroitin sulfate proteoglycan 4 antibody, sperm mitochondria associated cysteine rich protein antibody, CSPG4 antibody, Cspg4 antibody, SMCP antibody

Background:

Background: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Aliases: 4732461B14Rik antibody, AN2 antibody, AN2 proteoglycan antibody, Chondroitin sulfate proteoglycan 4 (melanoma-associated) antibody, Chondroitin sulfate proteoglycan 4 antibody, Chondroitin sulfate proteoglycan NG2 antibody, Cspg4 antibody, Cspg4 chondroitin sulfate proteoglycan 4 antibody, CSPG4_HUMAN antibody, HMW-MAA antibody, HSN tumor-specific antigen antibody, Kiaa4232 antibody, MCSP antibody, MCSPG antibody, MEL-CSPG antibody, Melanoma chondroitin sulfate proteoglycan antibody, Melanoma-associated chondroitin sulfate proteoglycan antibody, MELCSPG antibody, MSK16 antibody, NG2 antibody

UniProt: Q6UVK1

Pathways: Glycosaminoglycan Metabolic Process