MAPK11 antibody (pThr180, pTyr182) (HRP)

Catalog No. ABIN710585

The Rabbit Polyclonal anti-MAPK11 antibody is suitable to detect MAPK11 in samples from Human. It has been validated for WB, ELISA, IHC (p) and IHC (fro).

Quick Overview for MAPK11 antibody (pThr180, pTyr182) (HRP) (ABIN710585)

Target: MAPK11 (Mitogen-Activated Protein Kinase 11 (MAPK11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK11 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MAPK11 Antibody (HRP)

Binding Specificity: pThr180, pTyr182

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human MAPK11 around the phosphorylation site of Thr180+Tyr182

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MAPK11

Target: MAPK11 (Mitogen-Activated Protein Kinase 11 (MAPK11))

Alternative Name: MAPK11+

Background:

Synonyms: MAPK11phospho T180/Y182, Human p38Beta MAP kinase mRNA complete cds, MAP kinase 11, MAP kinase p38 beta, MAPK 11, Mapk11, Mitogen activated protein kinase 11, Mitogen activated protein kinase p38 2, Mitogen activated protein kinase p38 beta, mitogen-activated protein kinase 11, Mitogen-activated protein kinase p38 beta, MK11_HUMAN, p38 2, p38-2, P38B, p38Beta, P38BETA2, PRKM11, protein kinase mitogen activated 11, SAPK2, SAPK2B, Stress activated protein kinase 2, Stress-activated protein kinase 2.

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK11 is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

Gene ID: 5600

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Response to Water Deprivation, Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Hepatitis C, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteins