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COMMD1 antibody (AA 2-190) (Biotin)

COMMD1 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7148301
  • Target See all COMMD1 Antibodies
    COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))
    Binding Specificity
    • 15
    • 7
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-190
    Reactivity
    • 40
    • 22
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 44
    • 11
    Rabbit
    Clonality
    • 47
    • 8
    Polyclonal
    Conjugate
    • 26
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This COMMD1 antibody is conjugated to Biotin
    Application
    • 36
    • 20
    • 13
    • 13
    • 10
    • 8
    • 7
    • 5
    • 5
    • 3
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human COMM domain-containing protein 1 protein (2-190AA)
    Isotype
    IgG
    Top Product
    Discover our top product COMMD1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))
    Alternative Name
    COMMD1 (COMMD1 Products)
    Synonyms
    C2orf5 antibody, MURR1 antibody, murr1 antibody, commd1 antibody, si:ch211-213b8.2 antibody, DDBDRAFT_0184206 antibody, DDBDRAFT_0266452 antibody, DDB_0184206 antibody, DDB_0266452 antibody, COMMD1 antibody, MGC114682 antibody, AI256843 antibody, Murr1 antibody, U2/Mu antibody, copper metabolism domain containing 1 antibody, copper metabolism (Murr1) domain containing 1 antibody, COMM domain-containing protein 1 antibody, copper metabolism domain containing 1 L homeolog antibody, COMM domain containing 1 antibody, COMMD1 antibody, commd1 antibody, comd1 antibody, Commd1 antibody, commd1.L antibody
    Background

    Background: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141).

    Aliases: C2orf5 antibody, COMD1 antibody, COMD1_HUMAN antibody, COMM domain-containing protein 1 antibody, COMMD1 antibody, Copper metabolism (Murr1) domain containing 1 antibody, Copper metabolism domain containing 1 antibody, Copper metabolism gene MURR1 antibody, Copper metabolism MURR1 domain-containing protein 1 antibody, MGC27155 antibody, MURR1 antibody, Protein Murr1 antibody

    UniProt
    Q8N668
    Pathways
    Transition Metal Ion Homeostasis
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