CPNE1 antibody (AA 326-537)

Catalog No. ABIN7148511

The Rabbit Polyclonal anti-CPNE1 antibody has been validated for ELISA and IHC. It is suitable to detect CPNE1 in samples from Human.

Quick Overview for CPNE1 antibody (AA 326-537) (ABIN7148511)

Target: CPNE1 (Copine I (CPNE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPNE1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-CPNE1 Antibody

Binding Specificity: AA 326-537

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Copine-1 protein (326-537AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CPNE1

Target: CPNE1 (Copine I (CPNE1))

Alternative Name: CPNE1

Background:

Background: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation, induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).

Aliases: Copine 1 antibody, Copine I antibody, Copine-1 antibody, Copine1 antibody, CopineI antibody, COPN 1 antibody, COPN1 antibody, CPN 1 antibody, CPN1 antibody, CPNE 1 antibody, CPNE1 antibody, CPNE1_HUMAN antibody, MGC1142 antibody

UniProt: Q99829