CAND1 antibody (AA 1150-1230) (Biotin)

Catalog No. ABIN7148765

This Rabbit Polyclonal antibody specifically detects CAND1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for CAND1 antibody (AA 1150-1230) (Biotin) (ABIN7148765)

Target: CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAND1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CAND1 Antibody (Biotin)

Binding Specificity: AA 1150-1230

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cullin-associated NEDD8-dissociated protein 1 protein (1150-1230AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CAND1

Target: CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))

Alternative Name: CAND1

Background:

Background: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.

Aliases: CAND 1 antibody, Cand1 antibody, CAND1_HUMAN antibody, Cullin associated and neddylation dissociated 1 antibody, Cullin associated and neddylation dissociated protein 1 antibody, Cullin associated NEDD8 dissociated protein 1 antibody, Cullin-associated and neddylation-dissociated protein 1 antibody, Cullin-associated NEDD8-dissociated protein 1 antibody, DKFZP434M1414 antibody, FLJ10114 antibody, FLJ10929 antibody, FLJ38691 antibody, FLJ90441 antibody, KIAA0829 antibody, p120 CAND1 antibody, TATA binding protein interacting protein 120A antibody, TBP interacting protein antibody, TBP interacting protein of 120 kDa A antibody, TBP Interacting Protein TIP120A antibody, TBP-interacting protein 120A antibody, TBP-interacting protein of 120 kDa A antibody, TIP120 antibody, TIP120 protein antibody, TIP120A antibody

UniProt: Q86VP6

Pathways: Regulation of Actin Filament Polymerization