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IKZF1 antibody (AA 1-265) (Biotin)

The Rabbit Polyclonal anti-IKZF1 antibody has been validated for ELISA. It is suitable to detect IKZF1 in samples from Human.
Catalog No. ABIN7150362

Quick Overview for IKZF1 antibody (AA 1-265) (Biotin) (ABIN7150362)

Target

See all IKZF1 Antibodies
IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Reactivity

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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This IKZF1 antibody is conjugated to Biotin

Application

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ELISA
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    AA 1-265

    Cross-Reactivity

    Human

    Purification

    >95%, Protein G purified

    Immunogen

    Recombinant Human DNA-binding protein Ikaros protein (1-265AA)

    Isotype

    IgG
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

    Alternative Name

    IKZF1

    Background

    Background: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).

    Aliases: CLL associated antigen KW 6 antibody, DNA-binding protein Ikaros antibody, hIk 1 antibody, Hs.54452 antibody, IK1 antibody, Ikaros (zinc finger protein) antibody, IKAROS antibody, IKAROS family zinc finger 1 (Ikaros) antibody, Ikaros family zinc finger protein 1 antibody, Ikzf1 antibody, IKZF1_HUMAN antibody, LYF1 antibody, Lymphoid transcription factor LyF-1 antibody, PRO0758 antibody, Zinc finger protein subfamily 1A 1 (Ikaros) antibody, Zinc finger protein subfamily 1A 1 antibody, Zinc finger protein, subfamily 1A, member 1 antibody, ZNFN1A1 antibody

    UniProt

    Q13422

    Pathways

    Production of Molecular Mediator of Immune Response
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