CCDC111 antibody (AA 305-537)

Catalog No. ABIN7150406

Product Details anti-CCDC111 Antibody

Target: CCDC111 (Coiled-Coil Domain Containing 111 (CCDC111))

Binding Specificity: AA 305-537

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC111 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DNA-directed primase/polymerase protein (305-537AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CCDC111

Target: CCDC111 (Coiled-Coil Domain Containing 111 (CCDC111))

Alternative Name: PRIMPOL (CCDC111 Products)

Synonyms: BC065112 antibody, primase and DNA directed polymerase antibody, primase and polymerase (DNA-directed) antibody, PRIMPOL antibody, Primpol antibody

Background:

Background: DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH.

Aliases: CC111_HUMAN antibody, CCDC111 antibody, Coiled coil domain containing 111 antibody, Coiled-coil domain-containing protein 111 antibody, DNA-directed primase/polymerase protein antibody, MYP22 antibody, Primase and polymerase (DNA directed) antibody, PRIMPOL antibody

UniProt: Q96LW4