POLR3F antibody (AA 1-270) (Biotin)

Catalog No. ABIN7150467

The Rabbit Polyclonal anti-POLR3F antibody is suitable to detect POLR3F in samples from Human. It has been validated for ELISA.

Quick Overview for POLR3F antibody (AA 1-270) (Biotin) (ABIN7150467)

Target: POLR3F (Polymerase (RNA) III (DNA Directed) Polypeptide F, 39 KDa (POLR3F))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLR3F antibody is conjugated to Biotin

Application: ELISA

Product Details anti-POLR3F Antibody (Biotin)

Binding Specificity: AA 1-270

Purpose: POLR3F Antibody, Biotin conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human DNA-directed RNA polymerase III subunit RPC6 protein (1-270AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for POLR3F

Target: POLR3F (Polymerase (RNA) III (DNA Directed) Polypeptide F, 39 KDa (POLR3F))

Alternative Name: POLR3F

Background:

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Aliases: DNA directed RNA polymerase III 39 kDa polypeptide antibody, DNA directed RNA polymerase III 39 kDa polypeptide F antibody, DNA directed RNA polymerase III subunit F antibody, DNA directed RNA polymerase III subunit RPC6 antibody, DNA directed RNA polymerases III 39 kDa polypeptide antibody, DNA-directed RNA polymerase III subunit F antibody, DNA-directed RNA polymerase III subunit RPC6 antibody, MGC13517 antibody, Polr3f antibody, Polymerase (RNA) III (DNA directed) polypeptide F antibody, RNA polymerase III 39 kDa subunit antibody, RNA polymerase III C39 subunit antibody, RNA polymerase III subunit C6 antibody, RPC 39 antibody, RPC 6 antibody, RPC39 antibody, RPC6 antibody, RPC6_HUMAN antibody

UniProt: Q9H1D9