HERC5 antibody (AA 153-284)

Catalog No. ABIN7150946

Product Details anti-HERC5 Antibody

Target: HERC5 (Hect Domain and RLD 5 (HERC5))

Binding Specificity: AA 153-284

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HERC5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ISG15--protein ligase HERC5 protein (153-284AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HERC5

Target: HERC5 (Hect Domain and RLD 5 (HERC5))

Alternative Name: HERC5 (HERC5 Products)

Synonyms: HERC5 antibody, CEB1 antibody, CEBP1 antibody, HECT and RLD domain containing E3 ubiquitin protein ligase 5 antibody, hect domain and RLD 5 antibody, HERC5 antibody

Background:

Background: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence, ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.

Aliases: CEB1 antibody, CEBP1 antibody, Cyclin E binding protein 1 antibody, Cyclin-E-binding protein 1 antibody, E3 ISG15--protein ligase HERC5 antibody, HECT domain and RCC1 like domain containing protein 5 antibody, HECT domain and RCC1-like domain-containing protein 5 antibody, Hect domain and RLD 5 antibody, HECT E3 ubiquitin ligase antibody, HERC5 antibody, HERC5_HUMAN antibody, Herc6 antibody

UniProt: Q9UII4