CBX4 antibody (AA 401-560)

Catalog No. ABIN7150954

This anti-CBX4 antibody is a Rabbit Polyclonal antibody detecting CBX4 in ELISA and IHC. Suitable for Human.

Quick Overview for CBX4 antibody (AA 401-560) (ABIN7150954)

Target: CBX4 (Chromobox Homolog 4 (CBX4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-CBX4 Antibody

Binding Specificity: AA 401-560

Cross-Reactivity: Human

Purification: Antigen Affinity purified

Immunogen: Recombinant Human E3 SUMO-protein ligase CBX4 protein (401-560AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CBX4

Target: CBX4 (Chromobox Homolog 4 (CBX4))

Alternative Name: CBX4

Background:

Background: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A \\\'Lys-119\\\', rendering chromatin heritably changed in its expressibility.

Aliases: CBX 4 antibody, CBX4 antibody, Cbx4 chromobox homolog 4 (Drosophila Pc class) antibody, CBX4_HUMAN antibody, Chromobox homolog 4 (Pc class homolog, Drosophila) antibody, Chromobox homolog 4 antibody, Chromobox protein homolog 4 antibody, E3 SUMO protein ligase CBX 4 antibody, E3 SUMO protein ligase CBX4 antibody, E3 SUMO-protein ligase CBX4 antibody, hPc 2 antibody, hPc2 antibody, NBP 16 antibody, NBP16 antibody, NS5ATP1 binding protein 16 antibody, Pc 2 antibody, Pc class 2 homolog antibody, Pc class homolog antibody, Pc class homolog Drosophila antibody, PC2 antibody, Polycomb 2 homolog antibody

UniProt: O00257