PIAS4 antibody (AA 66-241)

Catalog No. ABIN7150970

This Rabbit Polyclonal antibody specifically detects PIAS4 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for PIAS4 antibody (AA 66-241) (ABIN7150970)

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIAS4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-PIAS4 Antibody

Binding Specificity: AA 66-241

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 SUMO-protein ligase PIAS4 protein (66-241AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIAS4

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Alternative Name: PIAS4

Background:

Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Aliases: E3 SUMO protein ligase PIAS4 antibody, E3 SUMO-protein ligase PIAS4 antibody, FLJ12419 antibody, MGC35296 antibody, PAIASgamma antibody, PIAS 4 antibody, PIAS gamma antibody, PIAS-gamma antibody, Pias4 antibody, PIAS4_HUMAN antibody, PIASG antibody, PIASgamma antibody, PIASy antibody, Protein inhibitor of activated STAT 4 antibody, Protein inhibitor of activated STAT protein 4 antibody, Protein inhibitor of activated STAT protein gamma antibody, Protein inhibitor of activated STAT protein PIASy antibody, Zinc finger MIZ type containing 6 antibody, ZMIZ 6 antibody, ZMIZ6 antibody

UniProt: Q8N2W9

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus