MKRN1 antibody (AA 109-209) (Biotin)

Catalog No. ABIN7151060

This Rabbit Polyclonal antibody specifically detects MKRN1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for MKRN1 antibody (AA 109-209) (Biotin) (ABIN7151060)

Target: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MKRN1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-MKRN1 Antibody (Biotin)

Binding Specificity: AA 109-209

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase makorin-1 protein (109-209AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MKRN1

Target: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Alternative Name: MKRN1

Background:

Background: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.

Aliases: E3 ubiquitin-protein ligase makorin-1 antibody, FLJ21334 antibody, HGNC:7112 antibody, Makorin antibody, Makorin ring finger protein 1 antibody, MKRN 1 antibody, mkrn1 antibody, MKRN1_HUMAN antibody, OTTHUMP00000212117 antibody, OTTHUMP00000212118 antibody, OTTHUMP00000212121 antibody, OTTHUMP00000212124 antibody, Ring finger protein 1 antibody, RING finger protein 61 antibody, RNF61 antibody

UniProt: Q9UHC7

Pathways: Chromatin Binding