RNF31 antibody (AA 421-700) (Biotin)

Catalog No. ABIN7151189

This Rabbit Polyclonal antibody specifically detects RNF31 in ELISA. It exhibits reactivity toward Human.

Quick Overview for RNF31 antibody (AA 421-700) (Biotin) (ABIN7151189)

Target: RNF31 (Ring Finger Protein 31 (RNF31))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF31 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-RNF31 Antibody (Biotin)

Binding Specificity: AA 421-700

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF31

Target: RNF31 (Ring Finger Protein 31 (RNF31))

Alternative Name: RNF31

Background:

Background: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (\\\'Met-1\\\'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Aliases: E3 ubiquitin protein ligase RNF31 antibody, FLJ10111 antibody, FLJ23501 antibody, HOIL 1L interacting protein antibody, HOIL-1-interacting protein antibody, HOIL1L interacting protein antibody, HOIP antibody, RING finger protein 31 antibody, RNF31 antibody, RNF31_HUMAN antibody, ZIBRA antibody, Zinc in between ring finger ubiquitin associated domain antibody, Zinc in-between-RING-finger ubiquitin-associated domain protein antibody

UniProt: Q96EP0