ZNRF3 antibody (AA 56-219) (Biotin)
Quick Overview for ZNRF3 antibody (AA 56-219) (Biotin) (ABIN7151319)
Target
See all ZNRF3 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 56-219
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Cross-Reactivity
- Human
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Purification
- >95%, Protein G purified
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Immunogen
- Recombinant Human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA)
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Isotype
- IgG
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anti-Zinc and Ring Finger Protein 3 (ZNRF3) (AA 56-219) antibody
ZNRF3 Reactivity: Human ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Zinc and Ring Finger Protein 3 (ZNRF3) (AA 120-165) antibodyZNRF3 Reactivity: Human, Mouse, Rat IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))
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Alternative Name
- ZNRF3
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Background
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Background: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Aliases: ZNRF3 antibody, KIAA1133 antibody, RNF203 antibody, E3 ubiquitin-protein ligase ZNRF3 antibody, EC 2.3.2.27 antibody, RING finger protein 203 antibody, RING-type E3 ubiquitin transferase ZNRF3 antibody, Zinc/RING finger protein 3 antibody
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UniProt
- Q9ULT6
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Pathways
- WNT Signaling
Target
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