EPAS1 antibody (AA 543-870)

Catalog No. ABIN7151747

This Rabbit Polyclonal antibody specifically detects EPAS1 in IHC, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for EPAS1 antibody (AA 543-870) (ABIN7151747)

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPAS1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-EPAS1 Antibody

Binding Specificity: AA 543-870

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Endothelial PAS domain-containing protein 1 protein (543-870AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EPAS1

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Alternative Name: EPAS1

Background:

Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5\'-[AG]CGTG-3\' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Aliases: Basic helix loop helix PAS protein MOP2 antibody, Basic-helix-loop-helix-PAS protein MOP2 antibody, bHLHe73 antibody, Class E basic helix-loop-helix protein 73 antibody, ECYT4 antibody, Endothelial PAS domain containing protein 1 antibody, Endothelial pas domain protein 1 antibody, Endothelial PAS domain-containing protein 1 antibody, EPAS 1 antibody, EPAS-1 antibody, EPAS1 antibody, EPAS1_HUMAN antibody, HIF 1 alpha like factor antibody, HIF 2 alpha antibody, HIF-1-alpha-like factor antibody, HIF-2-alpha antibody, HIF2-alpha antibody, HIF2A antibody, HLF antibody, Hypoxia inducible factor 2 alpha antibody, Hypoxia inducible factor 2 alpha subunit antibody, Hypoxia-inducible factor 2-alpha antibody, Member of PAS protein 2 antibody, Member of pas superfamily 2 antibody, MOP 2 antibody, MOP2 antibody, PAS domain-containing protein 2 antibody, PASD2 antibody

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect