EPH Receptor A5 antibody (AA 246-514) (Biotin)

Catalog No. ABIN7151844

The Rabbit Polyclonal anti-EPH Receptor A5 antibody has been validated for ELISA. It is suitable to detect EPH Receptor A5 in samples from Human.

Quick Overview for EPH Receptor A5 antibody (AA 246-514) (Biotin) (ABIN7151844)

Target: EPH Receptor A5 (EPHA5)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A5 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-EPH Receptor A5 Antibody (Biotin)

Binding Specificity: AA 246-514

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ephrin type-A receptor 5 protein (246-514AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EPH Receptor A5

Target: EPH Receptor A5 (EPHA5)

Alternative Name: EPHA5

Background:

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).

Aliases: Brain-specific kinase antibody, bsk antibody, CEK 7 antibody, Eck like sequence 1 antibody, EHK 1 antibody, EHK-1 antibody, EK7 antibody, Els 1 antibody, EPH homology kinase 1 antibody, EPH-like kinase 7 antibody, EPHA5 antibody, EPHA5_HUMAN antibody, Ephrin type A receptor 5 antibody, Ephrin type-A receptor 5 antibody, HEK 7 antibody, hEK7 antibody, Receptor protein tyrosine kinase HEK 7 antibody, Rek 7 antibody, TYRO 4 antibody, Tyrosine protein kinase receptor EHK 1 antibody

UniProt: P54756

Pathways: RTK Signaling