EPH Receptor A8 antibody (AA 45-249) (FITC)

Catalog No. ABIN7151857

This anti-EPH Receptor A8 antibody is a Rabbit Polyclonal antibody detecting EPH Receptor A8 in . Suitable for Human.

Quick Overview for EPH Receptor A8 antibody (AA 45-249) (FITC) (ABIN7151857)

Target: EPH Receptor A8 (EPHA8)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A8 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-EPH Receptor A8 Antibody (FITC)

Binding Specificity: AA 45-249

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Ephrin type-A receptor 8 protein (45-249AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EPH Receptor A8

Target: EPH Receptor A8 (EPHA8)

Alternative Name: EPHA8

Background:

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

Aliases: EPHA8 antibody, EEK antibody, HEK3 antibody, KIAA1459Ephrin type-A receptor 8 antibody, EC 2.7.10.1 antibody, EPH- and ELK-related kinase antibody, EPH-like kinase 3 antibody, EK3 antibody, hEK3 antibody, Tyrosine-protein kinase receptor EEK antibody

UniProt: P29322

Pathways: RTK Signaling