Exonuclease 1 antibody (AA 301-600) (HRP)

Catalog No. ABIN7152268

This anti-Exonuclease 1 antibody is a Rabbit Polyclonal antibody detecting Exonuclease 1 in ELISA. Suitable for Human.

Quick Overview for Exonuclease 1 antibody (AA 301-600) (HRP) (ABIN7152268)

Target: Exonuclease 1 (EXO1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exonuclease 1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-Exonuclease 1 Antibody (HRP)

Binding Specificity: AA 301-600

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Exonuclease 1 protein (301-600AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Exonuclease 1

Target: Exonuclease 1 (EXO1)

Alternative Name: EXO1

Background:

Background: 5\'->3\' double-stranded DNA exonuclease which may also possess a cryptic 3\'->5\' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5\' or 3\' to the mismatch. Also exhibits endonuclease activity against 5\'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5\'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.

Aliases: exo1 antibody, EXO1_HUMAN antibody, ExoI antibody, Exonuclease 1 antibody, Exonuclease I antibody, Exonuclease1 antibody, HEX1 antibody, hExo I antibody, hExo1 antibody, hExoI antibody, Rad2 nuclease family member homolog of S. cerevisiae exonuclease 1 antibody

UniProt: Q9UQ84

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response