EXOSC1 antibody (AA 9-195) (Biotin)

Catalog No. ABIN7152282

Product Details anti-EXOSC1 Antibody (Biotin)

Target: EXOSC1 (Exosome Component 1 (EXOSC1))

Binding Specificity: AA 9-195

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Exosome complex component CSL4 protein (9-195AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EXOSC1

Target: EXOSC1 (Exosome Component 1 (EXOSC1))

Alternative Name: EXOSC1 (EXOSC1 Products)

Synonyms: MGC86284 antibody, CGI-108 antibody, CSL4 antibody, Csl4p antibody, SKI4 antibody, Ski4p antibody, hCsl4p antibody, p13 antibody, 2610035C18Rik antibody, 2610104C07Rik antibody, 2610312F07Rik antibody, AI447561 antibody, exosome component 1 antibody, exosome component 1 L homeolog antibody, EXOSC1 antibody, exosc1.L antibody, exosc1 antibody, PTRG_05845 antibody, Exosc1 antibody

Background:

Background: Non-catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.

Aliases: 3'-5' exoribonuclease CSL4 homolog antibody, CGI 108 antibody, CGI-108 antibody, CSL4 antibody, CSL4 exosomal core protein homolog antibody, CSL4, S. cerevisiae, homolog of antibody, Csl4p antibody, EXOS1_HUMAN antibody, Exosc1 antibody, Exosomal core protein CSL4 antibody, Exosome complex component csl4 antibody, Exosome component 1 antibody, hCsl4p antibody, Homolog of yeast exosomal core protein CSL4 antibody, p13 antibody, RP11-452K12.9 antibody, SKI4 antibody, Ski4p antibody

UniProt: Q9Y3B2