EXOSC8 antibody (AA 2-276) (Biotin)

Catalog No. ABIN7152290

This Rabbit Polyclonal antibody specifically detects EXOSC8 in ELISA. It exhibits reactivity toward Human.

Quick Overview for EXOSC8 antibody (AA 2-276) (Biotin) (ABIN7152290)

Target: EXOSC8 (Exosome Component 8 (EXOSC8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC8 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-EXOSC8 Antibody (Biotin)

Binding Specificity: AA 2-276

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Exosome complex component RRP43 protein (2-276AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EXOSC8

Target: EXOSC8 (Exosome Component 8 (EXOSC8))

Alternative Name: EXOSC8

Background:

Background: Non-catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.

Aliases: bA421P11.3 antibody, CBP interacting protein 3 antibody, CIP3 antibody, EAP2 antibody, EC 3.1.13 antibody, EXOS8_HUMAN antibody, EXOSC8 antibody, Exosome complex component RRP43 antibody, Exosome complex exonuclease RRP43 antibody, Exosome component 8 antibody, OIP-2 antibody, OIP2 antibody, Opa interacting protein 2 antibody, Opa-interacting protein 2 antibody, OTTHUMP00000042274 antibody, p9 antibody, Ribosomal RNA processing protein 43 antibody, Ribosomal RNA processing protein 43, S. cerevisiae, homolog of antibody, Ribosomal RNA-processing protein 43 antibody, RP11 421P11.3 antibody, RRP43 antibody, Rrp43p antibody

UniProt: Q96B26

Pathways: SARS-CoV-2 Protein Interactome