FCRL3 antibody (AA 122-222) (Biotin)

Catalog No. ABIN7152659

This Rabbit Polyclonal antibody specifically detects FCRL3 in ELISA. It exhibits reactivity toward Human.

Quick Overview for FCRL3 antibody (AA 122-222) (Biotin) (ABIN7152659)

Target: FCRL3 (Fc Receptor-Like 3 (FCRL3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FCRL3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-FCRL3 Antibody (Biotin)

Binding Specificity: AA 122-222

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Fc receptor-like protein 3 protein (122-222AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FCRL3

Target: FCRL3 (Fc Receptor-Like 3 (FCRL3))

Alternative Name: FCRL3

Background:

Background: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).

Aliases: CD307c antibody, Fc receptor homolog 3 antibody, Fc receptor-like protein 3 antibody, FcR-like protein 3 antibody, FcRH3 antibody, FcRL3 antibody, FCRL3_HUMAN antibody, hIFGP3 antibody, IFGP family protein 3 antibody, IFGP3 antibody, Immune receptor translocation-associated protein 3 antibody, Immunoglobulin superfamily receptor translocation associated protein 3 antibody, IRTA3 antibody, SH2 domain-containing phosphatase anchor protein 2 antibody, SPAP2 antibody

UniProt: Q96P31