FZD4 antibody (AA 37-222)

Catalog No. ABIN7153185

The Rabbit Polyclonal anti-FZD4 antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect FZD4 in samples from Human.

Quick Overview for FZD4 antibody (AA 37-222) (ABIN7153185)

Target: FZD4 (Frizzled Family Receptor 4 (FZD4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FZD4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-FZD4 Antibody

Binding Specificity: AA 37-222

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Frizzled-4 protein (37-222AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FZD4

Target: FZD4 (Frizzled Family Receptor 4 (FZD4))

Alternative Name: FZD4

Background:

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Aliases: CD 344 antibody, CD 344 antigen antibody, CD344 antibody, CD344 antigen antibody, EVR1 antibody, FEVR antibody, Frizzled (Drosophila) homolog 4 antibody, Frizzled 4 antibody, Frizzled family receptor 4 antibody, Frizzled homolog 4 (Drosophila) antibody, Frizzled-4 antibody, Fz 4 antibody, Fz-4 antibody, Fz4 antibody, FZD4 antibody, FZD4_HUMAN antibody, FZD4S antibody, FzE4 antibody, GPCR antibody, hFz4 antibody, MGC34390 antibody, WNT receptor frizzled 4 antibody

UniProt: Q9ULV1

Pathways: WNT Signaling, Hormone Transport, Sensory Perception of Sound