Cyclin D2 antibody (AA 1-289)

Catalog No. ABIN7153389

The Rabbit Polyclonal anti-Cyclin D2 antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect Cyclin D2 in samples from Human. There is 1 publication available.

Quick Overview for Cyclin D2 antibody (AA 1-289) (ABIN7153389)

Target: Cyclin D2 (CCND2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin D2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Cyclin D2 Antibody

Binding Specificity: AA 1-289

Purpose: CCND2 Antibody

Cross-Reactivity: Mouse

Purification: Antigen Affinity purified

Immunogen: Recombinant Human G1/S-specific cyclin-D2 protein (1-289AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

References for anti-Cyclin D2 antibody (ABIN7153389)

Saha, Gavert, Brabletz, Ben-Ze'ev: "A Necessary Role for Cyclin D2 Induction During Colon Cancer Progression Mediated by L1." in: Cells, Vol. 13, Issue 21, (2024) (PubMed).

Target Details for Cyclin D2

Target: Cyclin D2 (CCND2)

Alternative Name: CCND2

Background:

Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Aliases: CCND 2 antibody, ccnd2 antibody, CCND2_HUMAN antibody, CyclinD2 antibody, G1/S specific cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, KIAK0002 antibody, MGC102758 antibody, MPPH3 antibody

UniProt: P30279

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases