Cyclin D2 antibody (AA 215-285) (Biotin)

Catalog No. ABIN7153391

This Rabbit Polyclonal antibody specifically detects Cyclin D2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for Cyclin D2 antibody (AA 215-285) (Biotin) (ABIN7153391)

Target: Cyclin D2 (CCND2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin D2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-Cyclin D2 Antibody (Biotin)

Binding Specificity: AA 215-285

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human G1/S-specific cyclin-D2 protein (215-285AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Cyclin D2

Target: Cyclin D2 (CCND2)

Alternative Name: CCND2

Background:

Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Aliases: CCND 2 antibody, ccnd2 antibody, CCND2_HUMAN antibody, CyclinD2 antibody, G1/S specific cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, KIAK0002 antibody, MGC102758 antibody, MPPH3 antibody

UniProt: P30279

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases