GABBR2 antibody (AA 60-310)

Catalog No. ABIN7153529

This Rabbit Polyclonal antibody specifically detects GABBR2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for GABBR2 antibody (AA 60-310) (ABIN7153529)

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABBR2 antibody is un-conjugated

Application: ELISA

Product Details anti-GABBR2 Antibody

Binding Specificity: AA 60-310

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Gamma-aminobutyric acid type B receptor subunit 2 protein (60-310AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GABBR2

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Alternative Name: GABBR2

Background:

Background: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Aliases: BcDNA:GH07312 antibody, CG6706 antibody, CT20836 antibody, D Gaba2 antibody, FLJ36928 antibody, G protein coupled receptor 51 antibody, G-protein coupled receptor 51 antibody, GAB B R2 antibody, GABA B R2 antibody, GABA B receptor 2 antibody, GABA-B receptor 2 antibody, GABA-B-R2 antibody, GABA-BR2 antibody, GABAB R2 antibody, GABABR 2 antibody, GABABR2 antibody, GABB R2 antibody, GABBR 2 antibody, Gabbr2 antibody, GABR2_HUMAN antibody, Gamma aminobutyric acid B receptor 2 antibody, Gamma aminobutyric acid GABA B receptor 2 antibody, Gamma aminobutyric acid type B receptor subunit 2 antibody, Gamma-aminobutyric acid type B receptor subunit 2 antibody, Gb 2 antibody, Gb2 antibody, GH07312 antibody, GPR 51 antibody, GPR51 antibody, GPRC 3B antibody, GPRC3B antibody, HG 20 antibody, HG20 antibody, HRIHFB2099 antibody, Metabotropic GABA B receptor subtype 2 antibody, OTTHUMP00000021776 antibody, OTTHUMP00000063797 antibody, R2 SUBUNIT antibody

UniProt: O75899

Pathways: cAMP Metabolic Process