SIP1 antibody (AA 1-280) (Biotin)

Catalog No. ABIN7153754

This Rabbit Polyclonal antibody specifically detects SIP1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for SIP1 antibody (AA 1-280) (Biotin) (ABIN7153754)

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIP1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SIP1 Antibody (Biotin)

Binding Specificity: AA 1-280

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Gem-associated protein 2 protein (1-280AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SIP1

Target: SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))

Alternative Name: GEMIN2

Background:

Background: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Aliases: Component of gems 2 antibody, Gem (nuclear organelle) associated protein 2 antibody, Gem associated protein 2 antibody, GEMI2_HUMAN antibody, Gemin-2 antibody, gemin2 antibody, SIP 1 antibody, SIP-1 antibody, SIP1 antibody, SIP1 delta antibody, SIP1-delta antibody, SMN interacting protein 1 antibody, SMN interacting protein 1 delta antibody, SMN-interacting protein 1 antibody, Survival interacting protein 1 antibody, Survival of motor neuron protein interacting protein 1 antibody, Survival of motor neuron protein-interacting protein 1 antibody

UniProt: O14893

Pathways: Ribonucleoprotein Complex Subunit Organization, Tube Formation