GRIA4 antibody (AA 733-883)

Catalog No. ABIN7153965

The Rabbit Polyclonal anti-GRIA4 antibody has been validated for ELISA, IHC and IF. It is suitable to detect GRIA4 in samples from Human.

Quick Overview for GRIA4 antibody (AA 733-883) (ABIN7153965)

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIA4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GRIA4 Antibody

Binding Specificity: AA 733-883

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Glutamate receptor 4 protein (733-883AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GRIA4

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Alternative Name: GRIA4

Background:

Background: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Aliases: AMPA 4 antibody, AMPA selective glutamate receptor 4 antibody, AMPA-selective glutamate receptor 4 antibody, AMPA4 antibody, GluA 4 antibody, GluA4 antibody, GluR 4 antibody, GluR D antibody, GluR-4 antibody, GluR-D antibody, GluR4 antibody, GLUR4C antibody, GLURD antibody, Glutamate receptor 4 antibody, Glutamate receptor ionotrophic AMPA 4 antibody, Glutamate receptor ionotropic antibody, GRIA 4 antibody, Gria4 antibody, GRIA4_HUMAN antibody, Ionotropic Glutamate receptor 4 antibody

UniProt: P48058

Pathways: PI3K-Akt Signaling