Glutaredoxin 2 antibody (AA 1-124)

Catalog No. ABIN7154050

This anti-Glutaredoxin 2 antibody is a Rabbit Polyclonal antibody detecting Glutaredoxin 2 in ELISA and IHC. Suitable for Human.

Quick Overview for Glutaredoxin 2 antibody (AA 1-124) (ABIN7154050)

Target: Glutaredoxin 2 (GRX2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutaredoxin 2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-Glutaredoxin 2 Antibody

Binding Specificity: AA 1-124

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Glutaredoxin-2, mitochondrial protein (1-124AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Glutaredoxin 2

Target: Glutaredoxin 2 (GRX2)

Alternative Name: GLRX2

Background:

Background: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Aliases: bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) antibody, bA101E13.1 antibody, CGI133 antibody, Glrx2 antibody, GLRX2_HUMAN antibody, Glutaredoxin-2 antibody, Glutaredoxin-2, mitochondrial antibody, GRX2 antibody, mitochondrial antibody

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis