GRB14 antibody (AA 294-397)

Catalog No. ABIN7154498

This Rabbit Polyclonal antibody specifically detects GRB14 in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for GRB14 antibody (AA 294-397) (ABIN7154498)

Target: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRB14 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GRB14 Antibody

Binding Specificity: AA 294-397

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Growth factor receptor-bound protein 14 protein (294-397AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GRB14

Target: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Alternative Name: GRB14

Background:

Background: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Aliases: GRB14Growth factor receptor-bound protein 14 antibody, GRB14 adapter protein antibody

UniProt: Q14449