RAN antibody (AA 1-216)

Catalog No. ABIN7154577

The Rabbit Polyclonal anti-RAN antibody has been validated for WB, ELISA and IHC. It is suitable to detect RAN in samples from Human.

Quick Overview for RAN antibody (AA 1-216) (ABIN7154577)

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAN antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RAN Antibody

Binding Specificity: AA 1-216

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human GTP-binding nuclear protein Ran protein (1-216AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RAN

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Alternative Name: RAN

Background:

Background: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.

Aliases: Androgen receptor associated protein 24 antibody, Androgen receptor-associated protein 24 antibody, ARA 24 antibody, ARA24 antibody, Gsp1 antibody, GTP binding nuclear protein RAN antibody, GTP-binding nuclear protein Ran antibody, GTPase Ran antibody, Guanosine triphosphatase Ran antibody, LPS antibody, OK/SW-cl.81 antibody, ran antibody, RAN member RAS oncogene family antibody, RAN_HUMAN antibody, RanGTPase antibody, Ras like protein TC4 antibody, Ras related nuclear protein antibody, Ras-like protein TC4 antibody, Ras-related nuclear protein antibody, RASL2 8 antibody, TC 4 antibody, TC4 antibody

UniProt: P62826

Pathways: Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus