TSC1 antibody (AA 101-344) (Biotin)

Catalog No. ABIN7154827

This anti-TSC1 antibody is a Rabbit Polyclonal antibody detecting TSC1 in ELISA. Suitable for Human.

Quick Overview for TSC1 antibody (AA 101-344) (Biotin) (ABIN7154827)

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-TSC1 Antibody (Biotin)

Binding Specificity: AA 101-344

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Hamartin protein (101-344AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: TSC1

Background:

Background: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.

Aliases: Hamartin antibody, kiaa0243 antibody, LAM antibody, TSC antibody, Tsc1 antibody, Tsc1 gene antibody, TSC1_HUMAN antibody, Tuberous sclerosis 1 antibody, Tuberous sclerosis 1 protein antibody, tumor suppressor antibody

UniProt: Q92574

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation